HFOT involves the administration of warm, humidified oxygen through nasal cannulas at high flow rates (20-70 L/min). This system is capable of delivering a precise, consistent FiO₂, adjustable from 21% to 100% oxygen. HFNC creates low levels of positive airway pressure, decreases pharyngeal dead space and work of breathing and improves comfort and oxygenation compared to conventional low flow systems. Unlike conventional oxygen therapy, HFNC improves safety in the anaesthesic setting by reducing the risk of hypoxaemia.
HFNC therapy has progressively been introduced at different points during the perioperative period: just before induction of anaesthesia, during procedures under different levels of sedation and in the postoperative period.
HFNC therapy is used at this stage for preoxygenation and apnoeic oxygenation in the induction of anaesthesia and when intubation is difficult. It prolongs safe apnoea time during induction (in manoeuvres such as laryngoscopy or the insertion of a laryngeal mask airway) and maintains better oxygenation in adults and children, especially in those with difficult airway or who are at risk of desaturation. For adults, HFNC is superior to an oxygen mask for preoxygenation and apnoeic oxygenation during rapid sequence induction and it helps keep the upper airway patent.
The use of HFNC during procedures performed outside the operating theatre under deep sedation has expanded over recent years. This is particularly interesting in gastrointestinal endoscopy, bronchoscopy and cardiological or endovascular procedures for patients with a moderate-high risk of desaturation. It is also indicated for patients at risk of hypoxaemia, respiratory depression and the need for airway management, without increasing the risk of adverse events.
A recent study found that HFNC therapy is not inferior to a laryngeal mask airway for short-term anaesthesia procedures that do not require neuromuscular blocking. However, close monitoring is required in these cases due to the risk of hypercapnia.
HFNC therapy can be used as respiratory support in thoracic surgery and non-intubated airway procedures. In some cases, it can be used during surgery for maintaining oxygenation, provided that it is monitored by trained anaesthesiologists.
Under these conditions, measures focus on preventing postanaesthetic respiratory failure. HFNC may avoid the need for escalation of respiratory support and reduce the duration of hospital stays, particularly in patients with a high risk of pulmonary complications.
HFOT is a new tool used in perioperative care. Its adaptability, effectiveness and safety make it a useful option for improving patient respiratory prognosis and increasing their safety in the anaesthetic setting, provided it is used with precise indication and expert monitoring. When used appropriately, HFNC can reduce respiratory complications, improve patient experience and optimise resources in the perioperative setting.
Anaesthesiologist, La Paz University Hospital
Al-Husinat L, Jouryyeh B, Rawashdeh A, Alenaizat A, Abushehab M, Amir MW, Al Modanat Z, Battaglini D, Cinnella G. High-Flow Oxygen Therapy in the Perioperative Setting and Procedural Sedation: Reviewing the current evidence. J Clin Med. 2023 Oct 23;12(20):6685. doi: 10.3390/jcm12206685. PMID: 37892823; PMCID: PMC10607541.
Ayuse T, Sawase H, Ozawa E, Nagata K, Komatsu N, Sanuki T, Kurata S, Mishima G, Hosogaya N, Nakashima S, Pinkham M, Tatkov S, Kazuhiko N. High-flow nasal cannula for prevention of hypercapnia in patients under intravenous anesthesia for endoscopic retrograde cholangiopancreatography. Medicine (Baltimore). 2020 May;99(19):e20036. doi: 10.1097/MD.0000000000020036. PMID: 32384464; PMCID: PMC7220513.
Chaudhuri D, Granton D, Wang DX, Burns KEA, Helviz Y, Einav S, Trivedi V, Mauri T, Ricard JD, Mancebo J, Frat JP, Jog S, Hernandez G, Maggiore SM, Mbuagbaw L, Hodgson CL, Jaber S, Goligher EC, Brochard L, Rochwerg B. High-Flow Nasal Cannula in the Immediate Postoperative Period: A systematic review and meta-analysis. Pecho. 2020 Nov;158(5):1934-1946. doi: 10.1016/j.chest.2020.06.038. Epub 2020 Jun 29. PMID: 32615190.
Frassanito L, Grieco DL, Vassalli F, Piersanti A, Scorzoni M, Ciano F, Zanfini BA, Catarci S, Catena U, Scambia G, Antonelli M, Draisci G. High-Flow Nasal Oxygen vs. Mechanical Ventilation via Laryngeal Mask in General Anesthesia without Muscle Paralysis: A Randomised Clinical Trial. Anesth Analg. 2025 Jul 21. doi: 10.1213/ANE.0000000000007620. Epub ahead of print. PMID: 40690380.
Mazzeffi MA, Petrick KM, Magder L, Greenwald BD, Darwin P, Goldberg EM, Bigeleisen P, Chow JH, Anders M, Boyd CM, Kaplowitz JS, Sun K, Terrin M, Rock P. High-Flow Nasal Cannula Oxygen in Patients Undergoing Anesthesia for Advanced Esophagogastroduodenoscopy: HIFLOW-ENDO, a randomised clinical trial. Anesth Analg. 2021 Mar 1;132(3):743-751. doi: 10.1213/ANE.0000000000004837. PMID: 32398433.
Munshi L, Mancebo J, Brochard LJ. Non-invasive respiratory support in adults with acute respiratory failure. N Engl J Med. 2022 Nov 3;387(18):1688-1698. doi: 10.1056/NEJMra2204556. PMID: 36322846.
NICE, 2021. High-flow nasal oxygen for non-theatre anaesthesia. Curr Opin Anaesthesiol. 2024 Aug 1;37(4):421-426. doi: 10.1097/ACO.0000000000001383. Epub 2024 Apr 30. PMID: 38841990.
Renda T, Corrado A, Iskandar G, Pelaia G, Abdalla K, Navalesi P. High-flow nasal oxygen therapy in intensive care and anesthesia. Br J Anaesth. 2018 Jan;120(1):18-27. doi: 10.1016/j.bja.2017.11.010. Epub 2017 Nov 21. PMID: 29397127.
Wittenstein J, Ball L, Pelosi P, Gama de Abreu M. High-flow nasal cannula oxygen therapy for thoracic surgery patients: what is the evidence? Curr Opin Anaesthesiol. 2019 Feb;32(1):44-49. doi: 10.1097/ACO.0000000000000682. PMID: 30543553.
Not sure what you’re looking for? Check out our resource library.